Fourth Semester M.Sc. Degree Examination, January 2021 BotanyBO 241 BIOINFORMATICS(2013 Admission Onwards)(Special Examination)

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J-5601

Fourth Semester M.Sc. Degree Examination, January 2021

Botany

BO 241 BIOINFORMATICS

(2013 Admission Onwards)

(Special Examination)

Time: 3 hours

1.Answer the following questions.

1.SCOP.

2.FASTA.

3.Gene finding.

4.GSDB.

5. TIGR.

6. BLOSUM.

7. DBMS.

8. Conserved sequences.

9. Modular proteins.

10. Autodock.

(10x1 = 10 Marks)

II. Answer the following questions in not more than 50 words.

11. (a) Briefly describe the salient features of genbank.

(b) Describe DOTPLOT.

12. (a) Describe the application of Clustal software.

(b) Differentiate between global alignment and local alignment.

13. (a) What is a specialized database?

(b) What is meant by threading in proteomics?

14. (a) Describe the software used in constructing dendrograms.

(b) Describe RASMOL with its advantage.

15. (a) Describe dynamic programming methods.

(b) Describe two methods of tertiary structure prediction of proteins.

III. Answer the following questions in not more than 150 words.

16. (a) Describe the contributions of Margaret Dayhoff.

(b) Describe a phylogenetic tree.

17. (a) Discuss the salient features of CATH.

(b) Describe the significance of homology modeling.

18. (a) Briefly describe the docking tools.

(b) Describe SNP and its relevance in genomics.

19. (a) Describe the procedure of data retrieval and analysis from any database.

(b) Describe the advantages of EST analysis.

20. (a) List out the nucleotide sequence databases.

(b) Describe about DDBJ.

21. (a) Explain genome annotation.

(b) Explain the gene prediction strategies.

22. (a) Describe the significance and application of CLUSTAL.

(b) Enumerate the features of trEMBLE.

(7 x 5 = 35 Marks)

IV. Answer the following questions in not more than 250 words.

23. (a) Describe advancement in molecular phylogeny based on comparative genomics.

(b) Enumerate the advancement in the field of human genomics.

24. (a) Describe the challenges and opportunities in proteomics.

(b) Describe the origin, history and development of biological databases.

(2 x 10 = 20 Marks)

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