Fourth Semester M.Sc. Degree Examination, September 2019BotanyBO 241: BIOINFORMATICS(2013 Admission onwards)

Reg. No.......

Name:........

G-5262

Fourth Semester M.Sc. Degree Examination, September 2019

Botany

BO 241: BIOINFORMATICS

(2013 Admission onwards)

Time: 3 Hours

I. Answer the following questions:

1. Contiguous sequences

2.Protein Motif

3.INDEL

4. DOTPLOT

5. J PRED

6. Phylogram

7.EST

8. Query sequence

9. TIGR

10. CLUSTAL

(10 x 1 = 10 Marks)

II. Answer the following questions in not more than 50 words:

11. (a) Describe protein atlas and its significance in the development of bioinformatics.

(b) Contribution of Frederick Sanger in advancement of proteomics.

12. (a) Describe Entrez with its significance.

(b) Describe the advantages of EST search in gene sequencing programme.

13. (a) What are the salient features of UniProt KB (SWISSPROT).

(b) Describe the features GenBank.

14. (a) Describe the concept of evolutionary tree.

(b) Describe RasMol.

15. (a) Significance of BioPerl software in Human Genome project

(b) Describe boutique databases.

(5 x 2 = 10 Marks)

III. Answer the following questions in not more than 150 words.

16. (a) Describe the major DNA databases.

(b) Describe the major protein databases.

17. (a) Describe the concept of molecular docking.

(b) Describe the relevance of mass spectrometry in proteomics.

18. (a) What is the relevance of metabolomics?

(b) Describe functional genomics with its application.

19. (a) Describe homology modeling with its significance.

(b) Describe SNPs with its role in bioinformatics.

20. (a) Describe protein secondary structure database.

(b) Describe how CADD is important in pharmaceutics

21. (a) Explain genome annotation.

(b) Explain the role of DNA microarray in genomics.

22. (a) Describe BLAST algorithm used in alignment.

(b) Briefly describe the contribution of Craig Venter in genomics.

(7 x 5= 35 Marks)

IV. Answer the following questions in not more than 250 words.

23. (a) Describe comparative genomics with its application in phylogeny.

(b) Enumerate the role of pharmacogenomics in healthcare.

24. (a) Describe the methods and tools used in protein structure prediction.

(b) Describe the milestones and achievements of human genome project.

(2 x 10 = 20 Marks)

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