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Fourth Semester M.Sc. Degree Examination, May 2020BotanyBO 241 BIOINFORMATICS(2013 Admission Onwards)

Reg. No.:.......
Name:.........
J-4881
Fourth Semester M.Sc. Degree Examination, May 2020
Botany
BO 241 BIOINFORMATICS
(2013 Admission Onwards)
Max. Marks: 75

I.Answer the following questions.

1.What are Secondary biological databases?
2.What is a Locus?
3. State the importance of E-value in sequence alignment?
4.Write the expansion of PHYLIP.
5. Distinguish proteome and proteomics.
6. Describe optimal alignment.
7.Define clade in a phylogenetic tree.
8.What is PIR?
9. List out any two tool used for molecular docking.
10. Write the name of submission tool for NCBI.
(10 x 1=10 Marks)


II. Answer the following questions in not more than 50 words.

11. (a) Give a short note on GenBank format.
OR
(b) Write the difference between scaled and unscaled phylogenetic trees.

12. (a) What are the two classes of data of UniProt?
OR
(b) State the difference between Orthologous and Xenologous sequences

13. (a) Write a brief note on character based phylogenetic analysis.
OR
(b) What is the role of NCBI in maintaining sequence database?

14. (a) Briefly explain genome annotation.
OR
(b) What are the desirable qualities of a lead compound?

15. (a) What do you mean by Gen-SNIP?
OR
(b) Differentiate global and local alignment.
(5 x 2 = 10 Marks)

III. Answer the following questions in not more than 150 words.

16. (a) Database heterogeneity is very common in bio-databases. How would you classify biodatabases based on the sources of data?
OR
(b) Explain the importance of Bioinformatics.

17. (a) Give detail about Chou-Fasman/GOR method of protein structure prediction.
OR
(b) Explain Bioinformatic tools for secondary structure prediction of a protein.

18. (a) PDB is considered to be one of the most important resources for bioinformatician. Why?
OR
(b) How tertiary structure of protein is predicted?

19. (a) Briefly explain transcriptomics.
OR
(b) What is Clustal W? How is it useful in multiple sequence alignment?

20. (a) What are the major extensions of BLAST? Highlight the major areas of their applications.
OR
(b) Enumerate the role of Mass spectrometry in protein identification.

21. (a) Write the importance of scoring matrices in sequence analysis.
OR
(b) Give a note on AutoDock and molegro virtual docker.
22. (a) Discuss about any one gene prediction tool.
OR
(b) How will you differentiate structural and functional genomics?

(7 x 5 = 35 Marks)

IV. Answer the following questions in not more than 250 words

23. (a) Bioinformatics has grown to such an extent that the time and space in developing and testing drugs has reduced significantly. Substantiate this argument by CADD.
OR
(b) Outline the impact of proteomics and genomics in the field of Bioinformatics.

24. (a) Explain sequence alignment. Describe the tools used for Sequence Analysis.
(b) Give a note on following:
BioPerl
GRAIL
Treeview
KEGG
Gold  
(2 x 10 = 20 Marks)



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